Entrainment of the Human Circadian Clock to the Natural Light-Dark Cycle

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Entrainment of the Human Circadian Clock to the Natural Light-Dark Cycle

The electric light is one of the most important human inventions. Sleep and other daily rhythms in physiology and behavior, however, evolved in the natural light-dark cycle [1], and electrical lighting is thought to have disrupted these rhythms. Yet how much the age of electrical lighting has altered the human circadian clock is unknown. Here we show that electrical lighting and the constructed...

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Circadian Entrainment to the Natural Light-Dark Cycle across Seasons and the Weekend

Reduced exposure to daytime sunlight and increased exposure to electrical lighting at night leads to late circadian and sleep timing [1-3]. We have previously shown that exposure to a natural summer 14 hr 40 min:9 hr 20 min light-dark cycle entrains the human circadian clock to solar time, such that the internal biological night begins near sunset and ends near sunrise [1]. Here we show that th...

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Entrainment of the human circadian clock.

Humans are an excellent model system for studying entrainment of the circadian clock in the real world. Unlike the situation in laboratory experiments, entrainment under natural conditions is achieved by different external signals as well as by internal signals generated by multiple feedbacks within the system (e.g., behavior-dependent light and temperature changes, melatonin levels, or regular...

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Simulation analysis for the effect of light-dark cycle on the entrainment in circadian rhythm.

Circadian rhythms of the living organisms are 24hr oscillations found in behavior, biochemistry and physiology. Under constant conditions, the rhythms continue with their intrinsic period length, which are rarely exact 24hr. In this paper, we examine the effects of light on the phase of the gene expression rhythms derived from the interacting feedback network of a few clock genes, taking advant...

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Most eukaryotic organisms as well as some prokaryotes (cyanobacteria) have an endogenous circadian clock that keeps track of the earth’s 24-h day/night cycle and regulates the activity of numerous metabolic pathways. The existence of the circadian clock as an endogenous feature of organisms and not merely a response to the presence or absence of sunlight was recognized in plants as early as the...

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ژورنال

عنوان ژورنال: Current Biology

سال: 2013

ISSN: 0960-9822

DOI: 10.1016/j.cub.2013.06.039